# STEAM

Models from the *evolutionary transfer learning* study (Qiu, Daza et al., 2026), which predict cell-class-specific chromatin accessibility across the developing mouse embryo. **STEAM** (Synteny-aware Transfer learning for Enhancer Activity Modeling) augments mouse training data with synteny-anchored enhancer orthologs from up to 241 mammalian genomes. Three models are provided: the final `STEAM_v1` model and the two precursor models (`evolution_naive`, `evolution_aware`) that illustrate the progression of the approach.

```{toctree}
:maxdepth: 1

steam_v1
steam_evolution_aware
steam_evolution_naive
```